F. Bromidge: search on Z-Library

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1

Model studies on a synthetically facile series of N-substituted phenyl-N′-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists

Steven M. Bromidge, Steven Dabbs, David T. Davies, Susannah Davies, D.Malcolm Duckworth, Ian T. Forbes, Angela Gadre, Peter Ham, Graham E. Jones, Frank D. King, Damian V. Saunders, Kevin M. Thewlis, D

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 186 KB

english, 1999

2

A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile

Stephen Bromidge, Paul C. Wilson, Andrew Whiting

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 248 KB

english, 1998

3

Identification of Trypanosoma brucei gambiense by PCR amplification of variant surface glycoprotein genes

Teresa Bromidge, Wendy Gibson, Ken Hudson, Peter Dukes

Journal:

Year:

1993

Language:

english

File:

PDF, 664 KB

english, 1993

4

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive dehydrogenases within intact rat-kidney mitochondria

James G. McCormack, Elaine S. Bromidge, Nicola J. Dawes

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1988

Language:

english

File:

PDF, 790 KB

english, 1988

5

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

M. Guscott, L.J. Bristow, K. Hadingham, T.W. Rosahl, M.S. Beer, J.A. Stanton, F. Bromidge, A.P. Owens, I. Huscroft, J. Myers, N.M. Rupniak, S. Patel, P.J. Whiting, P.H. Hutson, K.C. Fone, S.M. Biello,

Journal:

Neuropharmacology

Year:

2005

Language:

english

File:

PDF, 444 KB

english, 2005

6

Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands

Jenkins, Sarah M., Wadsworth, Harry J., Bromidge, Steven, Orlek, Barry S., Wyman, Paul A., Riley, Graham J., Hawkins, Julie

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 2.11 MB

english, 1992

7

Total synthesis of (�)-?-bulnesene via intramolecular cycloaddition of a 2-substituted 3-oxidopyrylium

Bromidge, Steven M., Sammes, Peter G., Street, Leslie J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1985

Language:

english

File:

PDF, 900 KB

english, 1985

8

5-HT1 Receptor Augmentation Strategies as Enhanced Efficacy Therapeutics for Psychiatric Disorders

Dawson, Lee, Bromidge, Steve

Journal:

Current Topics in Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 384 KB

english, 2008

9

ChemInform Abstract: A Parallel Combinatorial Approach to Locating Homochiral Lewis Acid Catalysts for the Asymmetric Aza-Diels—Alder Reaction of an Imino Dienophile.

S. BROMIDGE, P. C. WILSON, A. WHITING

Journal:

Year:

1999

File:

PDF, 31 KB

1999

10

ChemInform Abstract: N-(Indol-3-ylglyoxylyl)piperidines: High Affinity Agonists of Human GABA-A Receptors Containing the α1 Subunit.

Ian Collins, William B. Davey, Michael Rowley, Kathleen Quirk, Frances A. Bromidge, Ruth M. McKernan, Sally-Anne Thompson, Keith A. Wafford

Journal:

Year:

2000

File:

PDF, 37 KB

2000

11

ChemInform Abstract: 1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are Selective and Orally Active 5-HT2C Receptor Inverse Agonists.

Steven M. Bromidge, et al. et al.

Journal:

Year:

2000

File:

PDF, 36 KB

2000

12

ChemInform Abstract: 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: Novel and Selective 5-HT2C Receptor Inverse Agonists with Potential as Antidepressant/Anxiolytic Agents.

Steven M. Bromidge, et al. et al.

Journal:

Year:

2000

File:

PDF, 35 KB

2000

13

ChemInform Abstract: Phenyl Benzenesulfonamides Are Novel and Selective 5-HT6 Antagonists: Identification of N-(2,5-Dibromo-3-fluorophenyl) -4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).

Steven M. Bromidge, et al. et al.

Journal:

Year:

2001

File:

PDF, 36 KB

2001

14

ChemInform Abstract: Bicyclic Piperazinylbenzenesulfonamides Are Potent and Selective 5-HT6 Receptor Antagonists.

Steven M. Bromidge, Stephen E. Clarke, Frank D. King, Peter J. Lovell, Helen Newman, Graham Riley, Carol Routledge, Halina T. Serafinowska, Douglas R. Smith, David R. Thomas

Journal:

Year:

2002

File:

PDF, 35 KB

2002

15

Discovery of a Potent and Selective 5-ht5A Receptor Antagonist (I) by High-Throughput Chemistry.

David F. Corbett, Tom D. Heightman, Stephen F. Moss, Steven M. Bromidge, Sara A. Coggon, Mark J. Longley, Ana Maria Roa, Jennifer A. Williams, David R. Thomas

Journal:

Year:

2005

File:

PDF, 9 KB

2005

16

Discovery Process and Characterization of Novel Carbohydrazide Derivatives as Potent and Selective GHSR1a Antagonists

Fabio Maria Sabbatini, Romano Di Fabio, Mauro Corsi, Paolo Cavanni, Steve M. Bromidge, Yves St-Denis, Lucilla D'Adamo, Stefania Contini, Marilisa Rinaldi, Sebastien Guery, Chiara Savoia, Claudia Mundi

Journal:

Year:

2010

Language:

english

File:

PDF, 319 KB

english, 2010

17

Azabicyclo[3.1.0]hexane-1-carbohydrazides as Potent and Selective GHSR1a Ligands Presenting a Specific in vivo Behavior

Dr. Fabio Maria Sabbatini, Dr. Sergio Melotto, Dr. Giovanni Bernasconi, Dr. Steve M. Bromidge, Dr. Lucilla D'Adamo, Dr. Marilisa Rinaldi, Dr. Chiara Savoia, Dr. Claudia Mundi, Dr. Carla Di Francesco,

Journal:

Year:

2011

Language:

english

File:

PDF, 263 KB

english, 2011

18

Adaptation of the TdT assay for semi-quantitative flow cytometric detection of DNA strand breaks

Teresa J. Bromidge, Denise J. Howe, Stephen A. Johnson, Malcolm J. Phillips

Journal:

Cytometry Part A

Year:

1995

Language:

english

File:

PDF, 327 KB

english, 1995

19

3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity

Peter J. Atkinson, Steven M. Bromidge, Mark S. Duxon, Laramie M. Gaster, Michael S. Hadley, Beverley Hammond, Christopher N. Johnson, Derek N. Middlemiss, Stephanie E. North, Gary W. Price, Harshad K.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 282 KB

english, 2005

20

6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors

Steven M. Bromidge, Barbara Bertani, Manuela Borriello, Stefania Faedo, Laurie J. Gordon, Enrica Granci, Matthew Hill, Howard R. Marshall, Luigi P. Stasi, Valeria Zucchelli, Giancarlo Merlo, Alessia V

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 178 KB

english, 2008

21

Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry

David F. Corbett, Tom D. Heightman, Stephen F. Moss, Steven M. Bromidge, Sara A. Coggon, Mark J. Longley, Ana Maria Roa, Jennifer A. Williams, David R. Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 679 KB

english, 2005

22

Pyrazolopyridinones as functionally selective GABAA ligands

Wesley P. Blackaby, John R. Atack, Frances Bromidge, Richard Lewis, Michael G.N. Russell, Alison Smith, Keith Wafford, Ruth M. McKernan, Leslie J. Street, José L. Castro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

23

Imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands

Wesley P. Blackaby, John R. Atack, Frances Bromidge, José L. Castro, Simon C. Goodacre, David J. Hallett, Richard T. Lewis, George R. Marshall, Andrew Pike, Alison J. Smith, Leslie J. Street, David F.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 151 KB

english, 2006

24

8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors—Part II

Steven M. Bromidge, Barbara Bertani, Manuela Borriello, Andrea Bozzoli, Stefania Faedo, Massimo Gianotti, Laurie J. Gordon, Matthew Hill, Valeria Zucchelli, Jeannette M. Watson, Laura Zonzini

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 286 KB

english, 2009

25

5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3

Steven M. Bromidge, Roberto Arban, Barbara Bertani, Manuela Borriello, Anna-Maria Capelli, Romano Di-Fabio, Stefania Faedo, Massimo Gianotti, Laurie J. Gordon, Enrica Granci, Alessandra Pasquarello, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 642 KB

english, 2010

26

Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma

Denise Howe, Teresa Bromidge

Journal:

Leukemia Research

Year:

2006

Language:

english

File:

PDF, 90 KB

english, 2006

27

Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies

Teresa Bromidge, Caroline Lynas

Journal:

Leukemia Research

Year:

2002

Language:

english

File:

PDF, 87 KB

english, 2002

28

N-(Indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the α1 subunit

Ian Collins, William B Davey, Michael Rowley, Kathleen Quirk, Frances A Bromidge, Ruth M McKernan, Sally-Anne Thompson, Keith A Wafford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 153 KB

english, 2000

29

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents

Steven M. Bromidge, Steven Dabbs, Susannah Davies, D.Malcolm Duckworth, Ian T. Forbes, Graham E. Jones, Jerome Jones, Frank D. King, Damian V. Saunders, Thomas P. Blackburn, Vicky Holland, Guy A. Kenn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 141 KB

english, 2000

30

1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

Steven M. Bromidge, Susannah Davies, D.Malcolm Duckworth, Ian T. Forbes, Graham E. Jones, Jerome Jones, Frank D. King, Thomas P. Blackburn, Vicky Holland, Guy A. Kennett, Sean Lightowler, Derek N. Mid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 143 KB

english, 2000

31

Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)

Steven M Bromidge, Stephen E Clarke, Tracey Gager, Kerry Griffith, Phillip Jeffrey, Andrew J Jennings, Graham F Joiner, Frank D King, Peter J Lovell, Stephen F Moss, Helen Newman, Graham Riley, Derek

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 209 KB

english, 2001

32

Design and synthesis of azabicyclic muscarinic agonists incorporating an oxime ether functionality

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Steven Dabbs, Michael S. Hadley, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 306 KB

english, 1992

33

A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Steven Dabbs, Julie Hawkins, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 394 KB

english, 1992

34

Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT6 receptor

Steven M Bromidge, Kerry Griffith, Tom D Heightman, Andrew Jennings, Frank D King, Stephen F Moss, Helen Newman, Graham Riley, Carol Routledge, Halina T Serafinowska, David R Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 123 KB

english, 2001

35

1,2,5,6-tetrahydropyridine oxime ethers incorporating electron withdrawing groups are potent and selective muscarinic agonists

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Emma J. Collings, Steven Dabbs, Richard E. Faulkner, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 567 KB

english, 1994

36

Bridged 1,2,5,6-tetrahydropyridine esters and oxime ethers related to arecoline are novel and potent muscarinic agonists

Steven M. Bromidge, Frederick Cassidy, Michael S.G. Clark, Richard E. Faulkner, Michael S. Hadley, Barry S. Orlek, Graham J. Riley, Geoffrey Stemp

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 431 KB

english, 1994

37

Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists

Steven M Bromidge, Stephen E Clarke, Frank D King, Peter J Lovell, Helen Newman, Graham Riley, Carol Routledge, Halina T Serafinowska, Douglas R Smith, David R Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

38

Evaluation of an automated screening assay for von Willebrand Disease Type 2N

S. L. Taylor, E. Bromidge, G. F. Savidge, A. Alhaq

Journal:

International Journal of Laboratory Hematology (Blackwell)

Year:

2002

Language:

english

File:

PDF, 232 KB

english, 2002

39

Identification of amino acid residues responsible for the α5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABAA receptor

M. Anna Casula, Frances A. Bromidge, Gopalan V. Pillai, Peter B. Wingrove, Karine Martin, Karen Maubach, Guy R. Seabrook, Paul J. Whiting, Karen L. Hadingham

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 445 KB

english, 2001

40

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists

Caroline J. Goodacre, Steven M. Bromidge, David Clapham, Frank D. King, Peter J. Lovell, Mike Allen, Lorraine P. Campbell, Vicky Holland, Graham J. Riley, Kathryn R. Starr, Brenda K. Trail, Martyn D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

41

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists

Mahmood Ahmed, Michael A. Briggs, Steven M. Bromidge, Tania Buck, Lorraine Campbell, Nigel J. Deeks, Ashley Garner, Laurie Gordon, Dieter W. Hamprecht, Vicky Holland, Christopher N. Johnson, Andrew D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 260 KB

english, 2005

42

p53 intronic point mutation, aberrant splicing and telomeric associations in a case of B-chronic lymphocytic leukaemia

Teresa Bromidge, Christopher Lowe, Archie Prentice, Stephen Johnson

Journal:

British Journal of Haematology

Year:

2000

Language:

english

File:

PDF, 269 KB

english, 2000

43

Comparison of flow cytometric methods for the measurement of ZAP-70 expression in a routine diagnostic laboratory

G. GIBBS, T. BROMIDGE, D. HOWE, J. HOPKINS, S. JOHNSON

Journal:

International Journal of Laboratory Hematology (Blackwell)

Year:

2005

Language:

english

File:

PDF, 190 KB

english, 2005

44

Letter to the Editor

G. Gibbs, T. Bromidge, D. Howe, S. Johnson

Journal:

International Journal of Laboratory Hematology (Blackwell)

Year:

2007

Language:

english

File:

PDF, 428 KB

english, 2007

45

Detection of human papillomavirus genes in human oral tissue biopsies and cultures by polymerase chain reaction

Maitland, NJ, Bromidge, T, Cox, MF, Crane, IJ, Prime, SS, Scully, C

Journal:

British Journal of Cancer

Year:

1989

Language:

english

File:

PDF, 1.34 MB

english, 1989

46

[3H]-SB-269970 – A selective antagonist radioligand for 5-HT7 receptors

David R Thomas, Peter J Atkinson, Michael Ho, Steven M Bromidge, Peter J Lovell, Anthony J Villani, Jim J Hagan, Derek N Middlemiss, Gary W Price

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000

47

Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist

Jim J Hagan, Gary W Price, Phillip Jeffrey, Nigel J Deeks, Tania Stean, David Piper, Martin I Smith, Neil Upton, Andrew D Medhurst, Derek N Middlemiss, Graham J Riley, Peter J Lovell, Steven M Bromidg

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 209 KB

english, 2000

48

Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist

Carol Routledge, Steven M Bromidge, Stephen F Moss, Gary W Price, Warren Hirst, Helen Newman, Graham Riley, Tracey Gager, Tania Stean, Neil Upton, Stephen E Clarke, Anthony M Brown, Derek N Middlemiss

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 156 KB

english, 2000

49

Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue

Warren D Hirst, Jayne A L Minton, Steven M Bromidge, Stephen F Moss, Alison J Latter, Graham Riley, Carol Routledge, Derek N Middlemiss, Gary W Price

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 214 KB

english, 2000

50

In vitro chemosensitivity of chronic lymphocytic leukaemia to purine analogues – correlation with clinical course

Bromidge, T J, Turner, D L, Howe, D J, Johnson, S A, Rule, S A J

Journal:

Year:

1998

Language:

english

File:

PDF, 155 KB

english, 1998

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